Description

Butanamide, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-n-methoxy-n-methyl-, (3R)- CAS NO 245107-73-7 is a chiral, silyl-protected amino acid derivative of significant synthetic utility. This compound serves as a crucial advanced pharmaceutical intermediate (API) and a versatile building block in asymmetric synthesis. It is primarily required by research institutions and manufacturers engaged in the development of peptidomimetics, bioactive molecules, and novel therapeutic agents. Its defined stereochemistry and protective groups enable precise control over molecular architecture in complex organic transformations.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for peptide-based drugs.
• Peptidomimetic Research: Used in medicinal chemistry to design and synthesize peptide analogs with enhanced metabolic stability and bioavailability.
• Asymmetric Synthesis: Employed as a building block for introducing chiral centers in the synthesis of complex natural products and fine chemicals.
• Protecting Group Strategy: The tert-butyldimethylsilyl (TBDMS) group protects the hydroxyl function, allowing selective reactions at other sites of the molecule.
• Process Chemistry Development: Utilized in route scouting and optimization for the scalable production of chiral compounds under GMP conditions.
• Bioconjugation & Probe Development: Can be used to create labeled derivatives or conjugates for biochemical and diagnostic applications.

Basic Information

Product Name	Butanamide, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-n-methoxy-n-methyl-, (3R)-
CAS No.	245107-73-7
Molecular Formula	C13H29NO3Si
Molecular Weight	275.46 g/mol
Synonyms	(R)-3-((tert-Butyldimethylsilyl)oxy)-N-methoxy-N-methylbutanamide; (3R)-3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-N-methoxy-N-methylbutanamide; N-Methoxy-N-methyl-3-[(tert-butyldimethylsilyl)oxy]butanamide, (R)-; TBDMS-protected (R)-3-hydroxy-N-methoxy-N-methylbutyramide; (R)-Weinreb amide of 3-(TBDMSoxy)butanoic acid; Chiral silyl ether Weinreb amide; Advanced chiral synthon; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality management systems. Each batch is characterized and tested to ensure identity, purity, and chiral integrity, with specifications typically covering assay (by HPLC), chiral purity (by chiral HPLC), and control of related substances. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all analytical results. We support development and commercial projects requiring compliance with ICH guidelines and can provide material suitable for use under cGMP conditions upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.