Description

5-Trifluoromethyl-2H-Pyridazine-2-One is a high-value fluorinated heterocyclic building block, distinguished by the presence of a reactive trifluoromethyl group on the pyridazinone core. This compound is essential for medicinal chemistry research and development, offering a powerful handle for modulating the physicochemical properties of target molecules. It is primarily utilized by pharmaceutical and agrochemical R&D organizations seeking to incorporate fluorine motifs to enhance metabolic stability, lipophilicity, and bioavailability in novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly for kinase inhibitors and central nervous system (CNS) targeted therapies.
• Agrochemical Research: Used in the development of advanced herbicides and fungicides where the trifluoromethyl group contributes to biological activity and environmental stability.
• Material Science Precursor: Serves as a building block for specialty polymers and advanced organic electronic materials requiring fluorinated components.
• Chemical Biology Probes: Employed in the design of molecular probes and tags for studying biological systems and enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: A critical starting material for fine chemical manufacturers offering bespoke synthesis services to the life sciences industry.

Basic Information

Item	Detail
Product Name	5-Trifluoromethyl-2H-Pyridazine-2-One
CAS No.	244268-34-6
Molecular Formula	C5H3F3N2O
Molecular Weight	164.09 g/mol
Synonyms	5-(Trifluoromethyl)-1H-pyridazin-6-one; 5-(Trifluoromethyl)-2H-pyridazin-2-one; 5-(Trifluoromethyl)pyridazin-2(1H)-one; 5-Trifluoromethyl-2(1H)-pyridazinone; 5-Trifluoromethyl-1H-pyridazin-6-one; 244268-34-6; 5-Trifluoromethylpyridazin-2(1H)-one
EINECS	Contact for details

Quality Control

Our production of 5-Trifluoromethyl-2H-Pyridazine-2-One adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR and IR for structural confirmation, and KF for moisture content, to ensure consistency and reliability for critical R&D applications. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.