Description

2-Boc-Aminobenzyl Chloride is a protected amine derivative, specifically a benzyl chloride functionalized with a tert-butoxycarbonyl (Boc) protecting group on the aniline nitrogen. This compound is a critical building block in organic synthesis, valued for its dual functionality which allows for selective reactions and the construction of complex molecular architectures. It is primarily utilized by pharmaceutical R&D and fine chemical manufacturers for the synthesis of active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex drug molecules, particularly those containing benzylamine or aniline pharmacophores.
• Peptide Mimetics & PROTACs: Used in the construction of peptide-like structures and proteolysis-targeting chimeras (PROTACs) due to its orthogonal protecting group strategy.
• Agrochemical Synthesis: Serves as a building block for developing novel herbicides, fungicides, and plant growth regulators.
• Material Science: Employed in the synthesis of specialty polymers, dyes, and liquid crystals where aromatic amines are required.
• Cross-Coupling Reactions: Acts as an electrophilic partner in palladium-catalyzed cross-coupling reactions for C-C and C-N bond formation.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules in research applications.

Basic Information

Product Name	2-Boc-Aminobenzyl Chloride
CAS No.	243844-36-2
Molecular Formula	C12H16ClNO2
Molecular Weight	241.71 g/mol
Synonyms	1-[(tert-Butoxycarbonyl)amino]-2-(chloromethyl)benzene; N-(2-Chlorobenzyl)carbamic Acid tert-Butyl Ester; 2-(Chloromethyl)-N-Boc-aniline; tert-Butyl N-[(2-chlorophenyl)methyl]carbamate; 2-(Boc-amino)benzyl Chloride; N-Boc-2-aminobenzyl Chloride; Boc-2-Abz-Cl; (2-Chlorobenzyl)carbamic Acid 1,1-Dimethylethyl Ester
EINECS	Contact for details

Quality Control

Our 2-Boc-Aminobenzyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.