Description

[4-(Ethoxycarbonyl)Piperidin-1-Yl]Acetic Acid is a high-purity piperidine derivative carboxylic acid, serving as a critical building block in advanced organic synthesis. This compound is valued for its bifunctional nature, featuring both a protected amine group and a reactive carboxylic acid, enabling its use in constructing complex molecular architectures. It is primarily sought after by pharmaceutical R&D and fine chemical manufacturers for applications in medicinal chemistry and the development of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and metabolic disorder research.
• Peptidomimetic Chemistry: Used to introduce constrained piperidine scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Linker in Bioconjugation: The carboxylic acid group facilitates its use as a spacer or linker molecule in antibody-drug conjugates (ADCs) and other bioconjugation strategies.
• Agrochemical Research: Employed in the development of new herbicides and fungicides that require specific heterocyclic motifs.
• Material Science: Potential monomer or additive in the synthesis of specialized polymers with unique thermal or mechanical properties.

Basic Information

Product Name	[4-(Ethoxycarbonyl)Piperidin-1-Yl]Acetic Acid
CAS No.	224456-41-1
Molecular Formula	C10H17NO4
Molecular Weight	215.25 g/mol
Synonyms	1-Carboxymethyl-4-ethoxycarbonylpiperidine; 4-(Ethoxycarbonyl)-1-piperidineacetic Acid; 1-Piperidineacetic acid, 4-(ethoxycarbonyl)-; (4-Ethoxycarbonyl-piperidin-1-yl)-acetic acid; 4-Carbethoxy-1-piperidineacetic Acid; N-Carboxymethyl-4-ethoxycarbonylpiperidine; Ethyl 1-(carboxymethyl)piperidine-4-carboxylate
EINECS	Contact for details

Quality Control

Our [4-(Ethoxycarbonyl)Piperidin-1-Yl]Acetic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We adhere to cGMP principles where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.