Description

n-[(1S,2S)-2-Amino-1,2-Diphenylethyl]-4-Methylbenzenesulfonamide is a high-purity chiral sulfonamide derivative, serving as a critical building block in advanced organic synthesis. This compound is valued for its role as a versatile chiral auxiliary and ligand in asymmetric catalysis, enabling the production of enantiomerically pure pharmaceuticals and fine chemicals. It is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to control stereochemistry in complex molecular architectures.

Application

• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand in catalytic asymmetric reactions, including hydrogenations, aldol reactions, and alkylations.
• Pharmaceutical Intermediates: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) requiring high enantiomeric purity, particularly for central nervous system (CNS) and cardiovascular drugs.
• Catalyst Development: Used in the research and development of novel transition metal catalysts for stereoselective transformations.
• Fine Chemical Production: Integral to the manufacture of complex, high-value specialty chemicals where precise stereocontrol is mandatory.
• Academic & Industrial R&D: A valuable tool for methodological studies in organic chemistry and process development within contract research organizations (CROs) and CDMOs.

Basic Information

Product Name	n-[(1S,2S)-2-Amino-1,2-Diphenylethyl]-4-Methylbenzenesulfonamide
CAS No.	224454-16-4
Molecular Formula	C21H22N2O2S
Molecular Weight	366.48 g/mol
Synonyms	(1S,2S)-N-(p-Toluenesulfonyl)-1,2-diphenylethylenediamine; (1S,2S)-Ts-DPEN; (S,S)-TsDPEN; (1S,2S)-N-(4-Methylphenylsulfonyl)-1,2-diphenylethane-1,2-diamine; (S,S)-N-(p-Toluenesulfonyl)-1,2-diphenylethylenediamine; (S,S)-N-Tosyl-1,2-diphenylethylenediamine; (1S,2S)-N-Tosyl-1,2-diphenylethylenediamine; (S,S)-Ts-DPEN Ligand
EINECS	Contact for details

Quality Control

Our n-[(1S,2S)-2-Amino-1,2-Diphenylethyl]-4-Methylbenzenesulfonamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, to ensure compliance with high-purity standards for research and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.