Description

2-((S)-Dec-1-Yn-5-Yloxy)Tetrahydro-2H-Pyran is a chiral, non-racemic organic building block featuring a terminal alkyne and a protected alcohol functionality. This compound is valued for its role as a key synthetic intermediate in the production of complex, biologically active molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, asymmetric synthesis, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in the design and construction of molecular libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Asymmetric Synthesis: Serves as a chiral starting material or coupling partner in stereoselective reactions, including Sonogashira and other cross-coupling protocols.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organocatalysts for enantioselective transformations.
• Advanced Material Precursor: Potential use in the synthesis of functionalized polymers or liquid crystals with specific optical properties.

Basic Information

Product Name	2-((S)-Dec-1-Yn-5-Yloxy)Tetrahydro-2H-Pyran
CAS No.	223734-62-1
Molecular Formula	C₁₅H₂₆O₂
Molecular Weight	238.37 g/mol
Synonyms	(S)-5-((Tetrahydro-2H-pyran-2-yl)oxy)dec-1-yne; (S)-2-(Dec-1-yn-5-yloxy)tetrahydro-2H-pyran; THP-protected (S)-5-Hydroxy-1-decyne; (S)-1-Decyn-5-ol, 2-tetrahydropyranyl ether; (5S)-5-[(Oxan-2-yl)oxy]dec-1-yne; Chiral Dec-1-yn-5-yl THP Ether; (S)-5-(Tetrahydro-2H-pyran-2-yloxy)-1-decyne
EINECS	Contact for details

Quality Control

Our 2-((S)-Dec-1-Yn-5-Yloxy)Tetrahydro-2H-Pyran is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the high standards required for research and pharmaceutical development. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.