Description

Epicatechin 5-o-β-D-Glucuronide is a specific, high-purity glucuronide metabolite of the well-known flavan-3-ol, (-)-Epicatechin. This compound is of significant interest for its role in metabolic and pharmacokinetic studies, providing a critical reference standard for analyzing the bioavailability and biotransformation of dietary polyphenols. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, nutraceutical, and analytical chemistry sectors for method development, quality control, and advanced biochemical research.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the quantification and identification of epicatechin metabolites in drug metabolism and pharmacokinetic (DMPK) studies.
• Nutraceutical Research: Serves as a key analytical standard in research focused on the bioavailability, absorption, and health benefits of cocoa, tea, and other flavonoid-rich extracts.
• Clinical Biomarker Analysis: Essential for developing and validating LC-MS/MS or HPLC methods to measure this specific glucuronide conjugate in human plasma, serum, or urine samples.
• Enzyme Activity Assays: Employed as a substrate or standard in studies investigating the activity of UDP-glucuronosyltransferase (UGT) enzymes involved in phase II metabolism.
• Dietary Supplement Quality Control: Acts as a high-purity comparator for ensuring the accuracy and reliability of potency assays for complex botanical ingredients.

Basic Information

Product Name	Epicatechin 5-o-β-D-Glucuronide
CAS No.	223614-70-8
Molecular Formula	C21H22O12
Molecular Weight	466.39 g/mol
Synonyms	(-)-Epicatechin 5-O-β-D-glucuronide; Epicatechin-5-O-glucuronide; 5-O-β-D-Glucopyranuronosyl-(-)-epicatechin; EC5G; (2R,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-5-((2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-((carboxy)oxy)tetrahydro-2H-pyran-2-yl)oxy)-2H-1-benzopyran-3,7-diol
EINECS	Contact for details

Quality Control

Our Epicatechin 5-o-β-D-Glucuronide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the exacting standards required for research and development. A detailed Certificate of Analysis (COA) is provided, documenting purity, assay results, and chromatographic data.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residue on Ignition	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.