Description

S-Acetyl-Peg4-Alcohol (CAS NO 223611-42-5) is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a terminal acetyl-protected alcohol group. This compound is a critical intermediate for the synthesis of advanced bioconjugates, offering a reactive handle for further chemical modification while providing the beneficial solubility and pharmacokinetic properties of a PEG spacer. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require reliable, high-quality building blocks for developing novel therapeutics, drug delivery systems, and diagnostic agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of antibody-drug conjugates (ADCs), peptide-drug conjugates, and other targeted biotherapeutics.
• Linker Chemistry: Used to create cleavable or non-cleavable linkers in prodrug design, connecting active pharmaceutical ingredients (APIs) to targeting moieties.
• PEGylation Reagent: Serves as a precursor for activated PEG derivatives (e.g., NHS esters, maleimides) used to modify proteins, peptides, and nanoparticles to enhance stability and circulation time.
• Polymer Chemistry: Employed as a monofunctional initiator or monomer in the controlled synthesis of functionalized polymers and hydrogels.
• Diagnostic Probe Synthesis: Utilized in the construction of imaging agents and contrast media by conjugating dyes or radionuclides to targeting vectors.
• Material Science: Incorporated into surface coatings and biomaterials to improve biocompatibility and reduce non-specific binding.

Basic Information

Item	Detail
Product Name	S-Acetyl-Peg4-Alcohol
CAS No.	223611-42-5
Molecular Formula	C14H28O7
Molecular Weight	308.37 g/mol
Synonyms	2,5,8,11-Tetraoxatetradecan-14-ol, 14-acetate; 17-Acetoxy-3,6,9,12-tetraoxaheptadecan-1-ol; Acetyl-PEG4-alcohol; HO-PEG4-OAc; α-Acetyl-ω-hydroxy-tetraethylene glycol; Tetraethylene glycol monoacetate; 3,6,9,12-Tetraoxapentadecan-1-ol, 15-acetate; PEG4 monoacetate
EINECS	Contact for details

Quality Control

Our S-Acetyl-Peg4-Alcohol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere to maintain optimal quality.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.