Description

6-Acetylamino-4-Oxo-2-Spiro(n-Boc-Piperidine-4-Yl)-Benzopyran is a sophisticated spirocyclic benzopyran derivative, a key advanced intermediate in modern pharmaceutical research and development. This compound is valued for its complex molecular architecture, which serves as a crucial scaffold for synthesizing novel therapeutic agents targeting a range of diseases. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of new chemical entities and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly in medicinal chemistry programs.
• Protease Inhibitor Research: Used in the development of inhibitors for various proteolytic enzymes, leveraging its spirocyclic piperidine moiety.
• Kinase Inhibitor Scaffold: Serves as a core structure for designing and synthesizing potential kinase inhibitors for oncology and inflammatory diseases.
• Chemical Biology Probes: Employed in the creation of molecular probes to study biological pathways and protein function.
• Process Chemistry Development: Used for scaling up synthetic routes and optimizing manufacturing processes for complex target molecules.
• Academic & Contract Research: Essential for academic research and contract research organizations (CROs) focused on heterocyclic and medicinal chemistry.

Basic Information

Product Name	6-Acetylamino-4-Oxo-2-Spiro(n-Boc-Piperidine-4-Yl)-Benzopyran
CAS No.	223559-44-2
Molecular Formula	C21H26N2O5
Molecular Weight	386.45 g/mol
Synonyms	6-Acetamido-4-oxo-2-spiro(1-N-Boc-piperidine-4-yl)-4H-1-benzopyran; 2-(1-[(tert-Butoxy)carbonyl]-4-piperidinyl)-6-(acetylamino)-4H-1-benzopyran-4-one; 6-Acetylamino-4-oxo-2-spiro(1-N-Boc-4-piperidyl)-4H-chromene; tert-Butyl 4-(6-acetamido-4-oxo-4H-chromen-2-yl)piperidine-1-carboxylate; 6-Acetamido-2-(1-Boc-4-piperidyl)-4H-chromen-4-one; 2-(1-Boc-4-piperidyl)-6-acetamidochromen-4-one; 6-Acetylamino-2-spiro(1-N-Boc-piperidine-4-yl)-4H-chromen-4-one
EINECS	Contact for details

Quality Control

Our 6-Acetylamino-4-Oxo-2-Spiro(n-Boc-Piperidine-4-Yl)-Benzopyran is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP guidelines for advanced pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.