Description

(3R,6S)-6-Isopropyl-3-Methyl-5-Phenyl-3,6-Dihydro-2H-1,4-Oxazin-2-One is a high-purity, chiral 1,4-oxazin-2-one derivative, serving as a critical advanced intermediate in modern organic synthesis. Its value lies in its stereochemically defined structure, which is essential for constructing complex molecules with high enantiomeric purity. This compound is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers for applications in asymmetric synthesis and the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Asymmetric Synthesis: Utilized as a precursor or auxiliary in catalytic asymmetric reactions to introduce stereogenic centers with high selectivity.
• Agrochemical Research: Serves as a scaffold for developing novel, enantiomerically pure pesticides and herbicides.
• Ligand and Catalyst Development: Used in the research and preparation of novel chiral ligands for transition metal catalysis.
• Academic & Industrial R&D: A valuable compound for methodological studies in organic chemistry and process development.
• Fine Chemical Production: Employed in the custom synthesis of specialty chemicals requiring specific stereochemistry.

Basic Information

Product Name	(3R,6S)-6-Isopropyl-3-Methyl-5-Phenyl-3,6-Dihydro-2H-1,4-Oxazin-2-One
CAS No.	223244-09-5
Molecular Formula	C14H17NO2
Molecular Weight	231.29 g/mol
Synonyms	(3R,6S)-6-(1-Methylethyl)-3-methyl-5-phenyl-3,6-dihydro-2H-1,4-oxazin-2-one; (3R,6S)-6-Isopropyl-3-methyl-5-phenyl-morpholin-2-one; 5-Phenyl-6-isopropyl-3-methyl-3,6-dihydro-2H-1,4-oxazin-2-one (enantiomer); Chiral 1,4-Oxazin-2-one Derivative; (3R,6S)-Morpholinone derivative; 223244-09-5; (3R,6S)-6-Isopropyl-3-methyl-5-phenyl-3,6-dihydro-2H-1,4-oxazin-2-one
EINECS	Contact for details

Quality Control

Our (3R,6S)-6-Isopropyl-3-Methyl-5-Phenyl-3,6-Dihydro-2H-1,4-Oxazin-2-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.