Description

3-Bromo-2,6-Difluorophenol is a halogenated fluorophenol derivative that serves as a versatile and high-value synthetic building block in advanced organic chemistry. Its unique structure, featuring both bromine and fluorine substituents on the phenolic ring, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the difluorophenol moiety contributes to bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing aromatic units in electronic materials, enhancing thermal stability and optoelectronic performance.
• Polymer Chemistry: Acts as a monomer or functionalization agent for creating high-performance, halogenated polymers with specific flame-retardant or chemical resistance properties.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Ligand & Catalyst Development: Utilized in the design of novel chelating ligands for catalysis, leveraging the phenolic oxygen and halogen atoms for metal coordination.

Basic Information

Product Name	3-Bromo-2,6-Difluorophenol
CAS No.	221220-99-1
Molecular Formula	C6H3BrF2O
Molecular Weight	208.99 g/mol
Synonyms	2,6-Difluoro-3-bromophenol; 3-Bromo-2,6-difluorophenol; Phenol, 3-bromo-2,6-difluoro-; 3-Br-2,6-F2-Phenol
EINECS	Contact for details

Quality Control

Our 3-Bromo-2,6-Difluorophenol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and elemental analysis, to verify identity, potency, and impurity profiles. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring suitability for demanding R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed and stored upright to minimize moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.