Description

8-Methoxy-Chroman-3-Carboxylic Acid Ethyl Ester is a high-purity, versatile chemical intermediate of significant interest in advanced organic synthesis. Its unique chroman scaffold and functionalized ester group make it a valuable building block for the development of complex molecules. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and cardiovascular diseases.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging its heterocyclic structure for biological activity.
• Fine Chemical Production: Serves as a specialized building block for creating complex fragrances, flavors, and advanced material precursors.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies in organic chemistry and heterocyclic compound synthesis.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in related manufacturing processes.

Basic Information

Product Name	8-Methoxy-Chroman-3-Carboxylic Acid Ethyl Ester
CAS No.	221185-47-3
Molecular Formula	C13H16O4
Molecular Weight	236.26 g/mol
Synonyms	Ethyl 8-Methoxychroman-3-carboxylate; 8-Methoxy-3-chromancarboxylic Acid Ethyl Ester; 2H-1-Benzopyran-3-carboxylic acid, 8-methoxy-, ethyl ester; 8-Methoxy-3,4-dihydro-2H-1-benzopyran-3-carboxylic acid ethyl ester; Ethyl 8-methoxy-3,4-dihydro-2H-chromene-3-carboxylate
EINECS	Contact for details

Quality Control

Our 8-Methoxy-Chroman-3-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with every shipment, detailing all relevant specifications. We support cGMP compliance for pharmaceutical applications and can tailor quality protocols to meet specific client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat sources and incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.