Description

(6R)-4-Hydroxy-6-Phenethyl-6-Propyl-5,6-Dihydro-2H-Pyran-2-One CAS NO 221129-55-1 is a high-purity, chiral lactone derivative with a defined stereochemistry at the 6-position. This compound is a critical advanced pharmaceutical intermediate (API intermediate) valued for its role in synthesizing complex, biologically active molecules. It is primarily required by pharmaceutical R&D and fine chemical synthesis teams for the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Asymmetric Synthesis: Utilized in stereoselective chemical reactions to construct complex molecular architectures with high enantiomeric purity.
• Medicinal Chemistry Research: Employed in drug discovery programs for lead optimization and structure-activity relationship (SAR) studies.
• Process Chemistry Development: Used for scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	(6R)-4-Hydroxy-6-Phenethyl-6-Propyl-5,6-Dihydro-2H-Pyran-2-One
CAS No.	221129-55-1
Molecular Formula	C₁₆H₂₀O₃
Molecular Weight	260.33 g/mol
Synonyms	(6R)-4-Hydroxy-6-(2-phenylethyl)-6-propyl-5,6-dihydro-2H-pyran-2-one; (6R)-6-(2-Phenylethyl)-6-propyl-5,6-dihydro-4-hydroxy-2H-pyran-2-one; 6R-HPPD; (6R)-HPPD Lactone; Phenethyl-propyl-dihydroxypyranone; (R)-4-Hydroxy-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-2-one; CAS 221129-55-1
EINECS	Contact for details

Quality Control

Our production of (6R)-4-Hydroxy-6-Phenethyl-6-Propyl-5,6-Dihydro-2H-Pyran-2-One adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure high chemical and stereochemical purity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment. We support compliance with cGMP and ICH Q7 guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.