Description

(R)-n-Acetyl-6-(4-Aminophenyl)-4,5-Dihydro-5-Methyl-3(2H)-Pyridazinone CAS NO 220246-81-1 is a high-purity, chiral pyridazinone derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical chiral intermediate or building block for the synthesis of novel active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas. It is primarily sought after by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in drug discovery and process chemistry. The product's defined stereochemistry and functional groups make it a valuable scaffold for creating molecules with specific biological activity.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular research.
• Active Pharmaceutical Ingredient (API) Development: Used in the research and process development of potential new APIs requiring a specific (R)-enantiomer configuration.
• Medicinal Chemistry Research: A versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Asymmetric Synthesis: Employed in the development of new catalytic or stoichiometric asymmetric synthetic routes due to its chiral center.
• Reference Standard: Serves as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.
• Biochemical Research: Potential use as a tool compound for probing enzyme mechanisms or biological pathways.

Basic Information

Product Name	(R)-n-Acetyl-6-(4-Aminophenyl)-4,5-Dihydro-5-Methyl-3(2H)-Pyridazinone
CAS No.	220246-81-1
Molecular Formula	C14H17N3O2
Molecular Weight	259.31 g/mol
Synonyms	(R)-6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone, N-Acetyl derivative; (R)-5-Methyl-6-(4-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone acetate; (R)-N-Acetyl-6-(p-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone; (R)-enantiomer of Acetylaminophenylmethylpyridazinone; (R)-1-[6-(4-Aminophenyl)-5-methyl-4,5-dihydro-3-pyridazinyl]ethanone; (R)-6-(4-Aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone, 1-acetyl-; (R)-N-[6-(4-Aminophenyl)-5-methyl-4,5-dihydro-3-pyridazinyl]acetamide
EINECS	Contact for details

Quality Control

Our (R)-n-Acetyl-6-(4-Aminophenyl)-4,5-Dihydro-5-Methyl-3(2H)-Pyridazinone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with relevant guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.