Description

2-Propanone, 1,1-Difluoro-3-(Propylthio)- is a specialized fluorinated sulfur-containing ketone building block, identified by CAS No. 220142-40-5. This compound is valued for its unique molecular architecture, which combines a difluoroacetone core with a propylthioether side chain, making it a versatile intermediate for advanced synthesis. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical sectors for constructing complex molecules with tailored properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated motifs to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine and sulfur groups can enhance biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for specialty polymers and functional materials, exploiting its reactivity for introducing fluorine atoms into polymer backbones.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel ligands or catalyst systems for asymmetric synthesis and cross-coupling reactions.
• Fluorine Chemistry Exploration: A valuable substrate for studying new fluorination methodologies and the behavior of α,α-difluoroketone functional groups.

Basic Information

Product Name	2-Propanone, 1,1-Difluoro-3-(Propylthio)-
CAS No.	220142-40-5
Molecular Formula	C6H10F2OS
Molecular Weight	168.20 g/mol
Synonyms	1,1-Difluoro-3-(propylthio)acetone; 3-(Propylthio)-1,1-difluoroacetone; 1,1-Difluoro-3-(propylsulfanyl)propan-2-one; 1,1-Difluoro-3-propylsulfanylacetone; 2-Propanone, 1,1-difluoro-3-(propylthio)-; Acetone, 1,1-difluoro-3-(propylthio)-; DFPA (abbreviation)
EINECS	Contact for details

Quality Control

Our 2-Propanone, 1,1-Difluoro-3-(Propylthio)- is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including NMR, GC, and HPLC, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles against our stringent internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and fluorides. Due to its chemical nature, it should be handled in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.