Description

(25S)-Cyclohexyl-25-De(sec-Butyl)- 5-Demethoxy-5-Oxo-22,23-Dihydroavermectin A1A is a high-purity, semi-synthetic derivative of the avermectin family, a class of macrocyclic lactones renowned for their potent biological activity. This compound is a critical advanced intermediate for the research and development of novel agrochemicals and veterinary pharmaceuticals. It is primarily sought by R&D chemists and process development scientists in the agrochemical and animal health industries for synthesizing next-generation parasiticides with potentially improved efficacy and safety profiles.

Application

• Agrochemical Intermediate: A key building block for the synthesis of novel, high-performance insecticides and acaricides targeting resistant pest populations.
• Veterinary Pharmaceutical R&D: Used in the development of new endectocides and antiparasitic formulations for livestock and companion animals.
• Mode of Action Studies: Serves as a reference standard or probe in biochemical and pharmacological research to study glutamate-gated chloride channel modulation.
• Process Chemistry: Employed in scaling up and optimizing synthetic routes for the commercial production of avermectin-based active ingredients.
• Custom Synthesis: A starting material for the preparation of specialized analogs for proprietary research programs in crop protection and animal health.

Basic Information

Product Name	(25S)-Cyclohexyl-25-De(sec-Butyl)- 5-Demethoxy-5-Oxo-22,23-Dihydroavermectin A1A
CAS No.	220119-16-4
Molecular Formula	C₄₇H₇₀O₁₃
Molecular Weight	843.05 g/mol
Synonyms	5-Oxo-5-demethoxy-25-de(sec-butyl)-25-cyclohexyl-22,23-dihydroavermectin A1a; 5-Oxo-5-demethoxy-25-de-sec-butyl-25-cyclohexyl-22,23-dihydroavermectin A1a; 5-Oxo-5-demethoxy-25-de(1-methylpropyl)-25-cyclohexyl-22,23-dihydroavermectin A1a; (25S)-Cyclohexyl-25-De(sec-Butyl)-5-Demethoxy-5-Oxo-22,23-Dihydroavermectin A1A; Avermectin A1A derivative; 5-Keto-5-demethoxy avermectin intermediate
EINECS	Contact for details

Quality Control

Our (25S)-Cyclohexyl-25-De(sec-Butyl)- 5-Demethoxy-5-Oxo-22,23-Dihydroavermectin A1A is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for advanced pharmaceutical and agrochemical intermediates. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications such as assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0% Any single impurity ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.