Description

4,5,6,7-Tetrafluoro-3-Methyl-1H-Indazole is a high-value fluorinated heterocyclic building block, essential for advanced chemical synthesis. Its unique tetrafluoro-substituted indazole core offers significant advantages in modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in kinase inhibitor programs and central nervous system (CNS) targeted therapies.
• Agrochemical Synthesis: Used in the design and production of advanced herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, and organic electronic materials due to its electron-deficient aromatic system.
• Chemical Biology Probes: Employed in the synthesis of fluorinated probes and tags for studying biological processes and protein-ligand interactions.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, such as Suzuki or Buchwald-Hartwig amination, to construct complex polycyclic structures.

Basic Information

Product Name	4,5,6,7-Tetrafluoro-3-Methyl-1H-Indazole
CAS No.	220057-70-5
Molecular Formula	C8H4F4N2
Molecular Weight	204.13 g/mol
Synonyms	3-Methyl-4,5,6,7-tetrafluoro-1H-indazole; 4,5,6,7-Tetrafluoro-3-methylindazole; 1H-Indazole, 4,5,6,7-tetrafluoro-3-methyl-; 220057-70-5; Tetrafluoro-3-methyl-1H-indazole
EINECS	Contact for details

Quality Control

Our 4,5,6,7-Tetrafluoro-3-Methyl-1H-Indazole is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (typically 15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.