Description

Guanidinyl Naltrindole is a highly selective and potent delta opioid receptor (DOR) antagonist derived from the naltrindole chemical scaffold. This compound is a critical research tool for neuropharmacological studies, enabling the precise investigation of DOR-mediated signaling pathways and their physiological roles. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) focused on pain management, addiction, and neurological disorders.

Application

• Neuropharmacology Research: A key ligand for studying the structure, function, and distribution of delta opioid receptors in the central nervous system.
• Mechanism of Action Studies: Used to elucidate DOR-specific pathways in pain modulation, reward processing, and mood regulation.
• Drug Discovery & Development: Serves as a reference standard and pharmacological tool in the screening and development of novel analgesics with reduced side-effect profiles.
• In Vitro & Ex Vivo Assays: Employed in receptor binding assays, functional cellular assays (e.g., cAMP inhibition), and tissue bath experiments.
• Behavioral Pharmacology: Used in animal models to investigate the role of DOR in addiction, depression, and anxiety.
• Biochemical Tool: Useful for protein labeling and pull-down assays to study receptor-protein interactions.

Basic Information

Product Name	Guanidinyl Naltrindole
CAS No.	219655-57-9
Molecular Formula	C27H32N6O3
Molecular Weight	488.58 g/mol
Synonyms	GNTI; 17-Cyclopropylmethyl-6,7-dehydro-4,5α-epoxy-3,14-dihydroxy-6,7-2',3'-indolomorphinan-5′-guanidine; 5'-Guanidinonaltrindole; Guanidinonaltrindole; Naltrindole-5′-guanidine; 5'-GNTI; δ-Opioid receptor antagonist GNTI
EINECS	Contact for details

Quality Control

Our Guanidinyl Naltrindole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant standards for research chemicals, and specifications can be provided to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Solubility	Soluble in DMSO, Methanol; Slightly soluble in Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.