Description

Boc-Guanidine CAS NO 219511-71-4 is a high-purity, protected guanidine derivative widely used as a critical building block in organic synthesis and pharmaceutical research. Its primary value lies in providing a versatile and stable guanidine moiety that can be selectively deprotected under mild acidic conditions, enabling the controlled synthesis of complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and biotechnology sectors who are developing novel active ingredients, peptides, and molecular probes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, particularly those targeting cardiovascular diseases, neurological disorders, and infectious diseases.
• Peptide Synthesis: Used to introduce the guanidine functional group into peptide chains, which is crucial for mimicking arginine residues and enhancing binding affinity in bioactive peptides.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and plant growth regulators that require a guanidine core structure.
• Chemical Biology & Proteomics: Employed in the design and synthesis of activity-based probes, enzyme inhibitors, and tools for studying protein-protein interactions.
• Material Science: Utilized in the development of novel polymers, dendrimers, and supramolecular assemblies where guanidine groups can act as recognition or binding sites.
• Academic & R&D Laboratories: A fundamental reagent for methodological development in organic chemistry and for constructing complex natural product analogs.

Basic Information

Product Name	Boc-Guanidine
CAS No.	219511-71-4
Molecular Formula	C6H12N4O2
Molecular Weight	172.18 g/mol
Synonyms	1,3-Bis(tert-butoxycarbonyl)guanidine; N,N'-Di-Boc-guanidine; 1,3-Bis(Boc)guanidine; (Boc)2-Guanidine; tert-Butyl N-[(tert-butoxycarbonyl)carbamimidoyl]carbamate; Guanidine, N,N'-bis(1,1-dimethylethoxy)carbonyl]-; Di-Boc protected guanidine
EINECS	Contact for details

Quality Control

Every batch of Boc-Guanidine is manufactured under strict quality management protocols and undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming identity, purity, and impurity profiles. Our quality systems are designed to support cGMP and ISO guidelines for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 0.5%
Heavy Metals (as Pb)	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.