Description

Morpholine, 3-(Fluoromethyl)-4-(Phenylmethyl)-, (3R)- CAS NO 218594-80-0 is a chiral, fluorinated morpholine derivative, a high-value building block in modern synthetic organic chemistry. Its unique stereochemistry and fluorine substitution make it a critical intermediate for constructing complex molecules with targeted biological activity. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to develop new active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the fluorine atom and morpholine core can enhance bioavailability and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to control stereoselectivity.
• Chemical Biology Probes: Employed in the design of molecular probes for studying enzyme mechanisms and protein-ligand interactions due to its fluorine label potential.
• Material Science Research: Investigated as a monomer or functional additive for creating specialty polymers with specific optical or surface properties.

Basic Information

Product Name	Morpholine, 3-(Fluoromethyl)-4-(Phenylmethyl)-, (3R)-
CAS No.	218594-80-0
Molecular Formula	C12H16FNO
Molecular Weight	209.26 g/mol
Synonyms	(3R)-3-(Fluoromethyl)-4-(phenylmethyl)morpholine; (R)-3-(Fluoromethyl)-4-benzylmorpholine; (R)-4-Benzyl-3-(fluoromethyl)morpholine; 4-Benzyl-3-fluoromethylmorpholine, (R)-; UNII-4V7H1R9Q8R; 4V7H1R9Q8R; (R)-4-Benzyl-3-fluoromethyl-morpholine
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch is characterized and tested to ensure identity, purity, and enantiomeric excess meet rigorous standards. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing results from chiral HPLC, NMR, and other analytical methods. We support development projects with custom synthesis and purity grades upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.