Description

3-Methoxy-2-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate, 95.0+% (GC) is a high-purity, organosilicon-protected phenol derivative activated with a triflate leaving group. This compound is a critical building block in advanced organic synthesis, particularly valued for its role in facilitating challenging cross-coupling and functional group transformations under mild conditions. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in constructing biaryl ethers and complex phenolic scaffolds via Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Employed in the research and production of novel herbicides, fungicides, and insecticides where the introduction of a methoxy-silyl-protected phenolic moiety is required.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Used in the development of organic semiconductors, liquid crystals, and polymers where precise control over aromatic substitution patterns is essential.
• Chemical Biology Probes: Useful for the site-specific modification of biomolecules or in the synthesis of molecular probes for biochemical research.

Basic Information

Product Name	3-Methoxy-2-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate
CAS No.	217813-03-1
Molecular Formula	C11H15F3O4SSi
Molecular Weight	328.38 g/mol
Synonyms	2-Methoxy-6-(trimethylsilyl)phenyl trifluoromethanesulfonate; 2-(Trimethylsilyl)-3-methoxyphenyl triflate; 3-Methoxy-2-(trimethylsilyl)phenyl triflate; o-(Trimethylsilyl)-m-methoxyphenyl trifluoromethanesulfonate; TMS-Protected Methoxyphenyl Triflate; Trifluoromethanesulfonic acid 3-methoxy-2-(trimethylsilyl)phenyl ester
EINECS	Contact for details

Quality Control

Every batch of 3-Methoxy-2-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate is produced and analyzed under strict quality management protocols to ensure consistency and reliability for sensitive synthetic applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity (by GC), identity (by IR/NMR), and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.