Description

3-Pyridazinecarboxylicacid,2,3,4,5-Tetrahydro-4-Hydroxy-,Methylester,(3R,4R)-(9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its value lies in its functionalized, saturated pyridazine core and the presence of both hydroxy and ester groups, which make it a versatile intermediate for constructing complex molecular architectures. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemicals where precise stereochemistry is critical.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders or infectious diseases.
• Agrochemical Synthesis: Used in the synthesis of advanced, stereoselective herbicides, fungicides, or insecticides, where the specific (3R,4R) configuration can influence biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands or organocatalysts used in asymmetric synthesis to induce high enantioselectivity.
• Academic and R&D Laboratories: Employed in methodological studies and the construction of complex heterocyclic compounds for publication and proof-of-concept research.
• Fine Chemical Production: Integrated into multi-step synthetic routes for producing specialty chemicals with specific stereochemical requirements.

Basic Information

Product Name	3-Pyridazinecarboxylicacid,2,3,4,5-Tetrahydro-4-Hydroxy-,Methylester,(3R,4R)-(9Ci)
CAS No.	217447-50-2
Molecular Formula	C7H10N2O3
Molecular Weight	170.17 g/mol
Synonyms	(3R,4R)-Methyl 4-hydroxy-2,3,4,5-tetrahydro-1,2-diazine-3-carboxylate; (3R,4R)-4-Hydroxy-3,4,5,6-tetrahydropyridazine-3-carboxylic acid methyl ester; Methyl (3R,4R)-4-hydroxy-3,4,5,6-tetrahydropyridazine-3-carboxylate; (3R,4R)-Tetrahydro-4-hydroxy-3-pyridazinecarboxylic acid methyl ester; (3R,4R)-4-Hydroxy-2,3,4,5-tetrahydropyridazine-3-carboxylic acid methyl ester; (3R,4R)-4-Hydroxy-3,4,5,6-tetrahydro-2H-pyridazine-3-carboxylic acid methyl ester; Chiral pyridazine derivative; (3R,4R)-CAS 217447-50-2.
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is fully characterized using advanced analytical techniques including chiral HPLC, NMR, and mass spectrometry to confirm identity, stereochemical purity, and chemical purity. Certificates of Analysis (COA) detailing all relevant specifications are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation, especially after opening the original container. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.