Description

trans-4-Aminotetrahydropyran-3-Ol is a high-purity, functionalized tetrahydropyran derivative that serves as a critical chiral building block in advanced organic synthesis. Its unique structure, featuring both amino and hydroxyl groups on a saturated oxygen-containing heterocycle, makes it a versatile intermediate for constructing complex molecular architectures. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to introduce key pharmacophores and modulate the physicochemical properties of target molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in protease inhibitor and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and fungicides, where its heterocyclic scaffold contributes to biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probe Development: Employed in the synthesis of molecular probes and tool compounds for studying biological pathways and enzyme function.
• Material Science Research: Acts as a monomer or functional modifier in the synthesis of specialty polymers and advanced materials.

Basic Information

Product Name	trans-4-Aminotetrahydropyran-3-Ol
CAS No.	215940-92-4
Molecular Formula	C5H11NO2
Molecular Weight	117.15 g/mol
Synonyms	(3R,4S)-4-Amino-3-hydroxytetrahydropyran; (3S,4R)-4-Amino-3-hydroxytetrahydropyran; 4-Amino-3-hydroxytetrahydropyran (trans); 3-Hydroxy-4-aminotetrahydropyran; trans-4-Amino-3-hydroxytetrahydropyran; 4-Aminotetrahydropyran-3-ol; THP-Amino Alcohol Derivative
EINECS	Contact for details

Quality Control

Every batch of trans-4-Aminotetrahydropyran-3-Ol is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity consistent with pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.