Description

tert-Butyl (3R)-3-(Hydroxymethyl)Morpholine-4-Carboxylate is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. Its value lies in its defined stereochemistry and functional groups, which are critical for constructing complex active pharmaceutical ingredients (APIs) with high enantiomeric purity. This compound is essential for research and production in the pharmaceutical industry, particularly for the synthesis of novel therapeutics targeting the central nervous system and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug molecules, particularly those requiring a morpholine scaffold.
• API Development: Used in research and development for constructing novel Active Pharmaceutical Ingredients (APIs) with specific stereochemical configurations.
• Asymmetric Synthesis: Serves as a versatile building block in asymmetric synthesis for creating enantiomerically pure compounds.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies for new drug candidates.
• Process Chemistry: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Manufacturing (CMO/CDMO): Supplied to contract research and manufacturing organizations for custom synthesis projects.

Basic Information

Product Name	tert-Butyl (3R)-3-(Hydroxymethyl)Morpholine-4-Carboxylate
CAS No.	215917-99-0
Molecular Formula	C10H19NO4
Molecular Weight	217.26 g/mol
Synonyms	(R)-tert-Butyl 3-(hydroxymethyl)morpholine-4-carboxylate; (3R)-3-(Hydroxymethyl)morpholine-4-carboxylic acid tert-butyl ester; tert-Butyl (R)-3-(hydroxymethyl)morpholine-4-carboxylate; 4-Morpholinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester, (3R)-; (R)-3-(Hydroxymethyl)-N-Boc-morpholine; (R)-N-Boc-3-hydroxymethylmorpholine; (R)-3-Hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl (3R)-3-(Hydroxymethyl)Morpholine-4-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity, to ensure compliance with exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.