Description

Boc-Thionoleu-1-(6-Nitro)Benzotriazolide is a specialized, high-purity chemical building block used in advanced organic synthesis. This compound is critical for researchers and manufacturers requiring precise, protected intermediates for constructing complex molecules, particularly in peptide and pharmaceutical chemistry. It is primarily utilized by R&D laboratories and production facilities in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic agents and bioactive compounds.

Application

• Peptide Synthesis Intermediate: Serves as a key, protected amino acid derivative for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics.
• Pharmaceutical Research & Development: Used as a building block in the discovery and development of new active pharmaceutical ingredients (APIs), especially those targeting protease-related pathways.
• Bioconjugation Chemistry: Employed in the design and synthesis of linker molecules for antibody-drug conjugates (ADCs) and other targeted drug delivery systems.
• Combinatorial Chemistry Libraries: A valuable reagent for generating diverse chemical libraries for high-throughput screening in drug discovery programs.
• Fine Chemical Synthesis: Acts as a precursor in the multi-step synthesis of specialized fine chemicals and custom organic molecules for various industrial applications.

Basic Information

Product Name	Boc-Thionoleu-1-(6-Nitro)Benzotriazolide
CAS No.	214750-70-6
Molecular Formula	C20H28N4O5S
Molecular Weight	436.53 g/mol
Synonyms	1-[(1,1-Dimethylethoxy)carbonyl]-2-methyl-1-(6-nitro-1H-benzotriazol-1-yl)propyl thionoformate; tert-Butyl (1-((6-nitro-1H-benzo[d][1,2,3]triazol-1-yl)thio)-2-methyl-1-oxopropan-2-yl)carbamate; Boc-Thionoleucine 6-Nitrobenzotriazolide; Boc-ThioLeu-ONbt; N-(tert-Butoxycarbonyl)-S-(6-nitro-1H-benzotriazol-1-yl)-L-thioleucine; (S)-2-((tert-Butoxycarbonyl)amino)-4-methyl-1-((6-nitro-1H-benzo[d][1,2,3]triazol-1-yl)thio)pentan-1-one
EINECS	Contact for details

Quality Control

Every batch of Boc-Thionoleu-1-(6-Nitro)Benzotriazolide is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are supported by a detailed Certificate of Analysis (COA) that includes data from HPLC, NMR, and mass spectrometry. We adhere to cGMP guidelines for pharmaceutical intermediates, ensuring reliable supply and traceability for critical research and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.