Description

2'-Chloro-6-Fluoroflavone is a fluorinated and chlorinated derivative of the flavone core structure, a privileged scaffold in medicinal chemistry. This compound matters as a high-value synthetic intermediate and a key building block for the development of novel bioactive molecules. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in creating new drug candidates, particularly for applications in oncology, neurology, and inflammation research.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel small-molecule drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of therapeutic agents.
• Kinase Inhibitor Development: A valuable building block for constructing potential kinase inhibitors, a major class of targeted cancer therapies.
• Biochemical Probe Synthesis: Employed in creating specialized probes for studying enzyme function and cellular signaling processes.
• Flavonoid Analog Production: Used to synthesize advanced analogs of natural flavonoids for enhanced biological activity and metabolic stability.
• Academic & Contract Research: Essential for universities and CROs conducting fundamental research in organic synthesis and pharmacology.

Basic Information

Product Name	2'-Chloro-6-Fluoroflavone
CAS No.	213894-65-6
Molecular Formula	C₁₅H₈ClFO₂
Molecular Weight	274.67 g/mol
Synonyms	6-Fluoro-2'-chloroflavone; 2'-Chloro-6-fluorobenzopyran-4-one; Flavone, 2'-chloro-6-fluoro-; 2-(2-Chlorophenyl)-6-fluoro-4H-chromen-4-one; 2'-Chloro-6-fluoro-4H-1-benzopyran-4-one; 6-Fluoro-2'-(chloro)flavone
EINECS	Contact for details

Quality Control

Our 2'-Chloro-6-Fluoroflavone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. We provide comprehensive analytical data, including HPLC purity, identity confirmation (IR, NMR), and residual solvent analysis. A detailed Certificate of Analysis (COA) is supplied with each batch to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.