Description

(2S)-2-[[[5-(Trimethylstannyl)-3-Pyridinyl]Oxy]Methyl]-1-Azetidinecarboxylic Acid, T-Butyl Ester is a high-value organotin intermediate featuring a chiral azetidine core, designed for advanced synthetic applications. Its molecular architecture, combining a pyridinyl-trimethylstannyl moiety with a protected azetidinecarboxylate, makes it a critical building block for constructing complex, biologically active molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients through precise cross-coupling and functionalization reactions.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of potential drug candidates, especially for central nervous system (CNS) and anti-infective targets.
• Agrochemical Research: Used in developing novel pesticides and herbicides, leveraging the organotin moiety for specific biological activity.
• Ligand Synthesis: Acts as a starting material for creating sophisticated chiral ligands used in asymmetric catalysis.
• Material Science: Employed in the research of organometallic polymers and advanced materials with specific electronic properties.
• Stille Cross-Coupling Reactions: The trimethylstannyl group makes it an excellent reagent for palladium-catalyzed cross-coupling to form new carbon-carbon bonds with high fidelity.
• Chemical Biology Probes: Utilized to create labeled compounds or probes for studying biological mechanisms and pathways.

Basic Information

Product Name	(2S)-2-[[[5-(Trimethylstannyl)-3-Pyridinyl]Oxy]Methyl]-1-Azetidinecarboxylic Acid, T-Butyl Ester
CAS No.	213766-21-3
Molecular Formula	C18H28N2O3Sn
Molecular Weight	439.13 g/mol
Synonyms	tert-Butyl (2S)-2-({[5-(trimethylstannyl)pyridin-3-yl]oxy}methyl)azetidine-1-carboxylate; (2S)-2-({[5-(Trimethylstannyl)pyridin-3-yl]oxy}methyl)-1-(tert-butoxycarbonyl)azetidine; 1-Boc-2S-({[5-(Trimethylstannyl)-3-pyridyl]oxy}methyl)azetidine; Azetidine-1-carboxylic acid, 2-[[[5-(trimethylstannyl)-3-pyridinyl]oxy]methyl]-, 1,1-dimethylethyl ester, (2S)-; 213766-21-3; Stannane, (3-[[(2S)-1-[(1,1-dimethylethoxy)carbonyl]-2-azetidinyl]methoxy]-5-pyridinyl)trimethyl-
EINECS	Contact for details

Quality Control

Every batch of (2S)-2-[[[5-(Trimethylstannyl)-3-Pyridinyl]Oxy]Methyl]-1-Azetidinecarboxylic Acid, T-Butyl Ester is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC, NMR, and elemental analysis, to ensure high chemical and chiral purity and compliance with customer specifications. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and should be handled under an inert atmosphere when appropriate to ensure long-term stability. Keep away from strong alkali and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.