Description

Cyclopropanecarboxylic Acid, 2-[(Acetylamino)Methyl]-, (1R,2R)-Rel- (9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its core value lies in its unique cyclopropane ring fused with a functionalized amino acid backbone, making it a critical intermediate for constructing complex, biologically active molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients with specific three-dimensional architectures. Its defined stereochemistry ensures predictable and reproducible outcomes in asymmetric synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new Active Pharmaceutical Ingredients (APIs), especially in antiviral, anticancer, and neurological drug candidates.
• Agrochemical Synthesis: Used in the design and synthesis of novel herbicides, fungicides, and insecticides where the cyclopropane moiety can enhance biological activity and stability.
• Peptidomimetics & Bioactive Molecule Design: Serves as a constrained, non-natural amino acid analog for developing peptide mimics and other bioactive compounds with improved metabolic stability and receptor selectivity.
• Asymmetric Catalysis & Method Development: Employed as a test substrate or ligand precursor in academic and industrial research focused on developing new stereoselective synthetic methodologies.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme mechanisms and protein-protein interactions within biological systems.

Basic Information

Product Name	Cyclopropanecarboxylic Acid, 2-[(Acetylamino)Methyl]-, (1R,2R)-Rel- (9Ci)
CAS No.	213757-85-8
Molecular Formula	C8H13NO3
Molecular Weight	171.19 g/mol
Synonyms	(1R,2R)-2-(Acetamidomethyl)cyclopropanecarboxylic Acid; rel-(1R,2R)-2-[(Acetylamino)methyl]cyclopropanecarboxylic Acid; (1R,2R)-2-(Acetamidomethyl)cyclopropane-1-carboxylic Acid; N-[(1R,2R)-2-(Carboxy)cyclopropyl]methylacetamide; (1R,2R)-ACCA; A Chiral Cyclopropane Amino Acid Derivative
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high chemical purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC, NMR, and chiral analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity (assay), enantiomeric excess, and impurity profiles. We support development projects with custom synthesis and specification tailoring to meet specific research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent degradation from atmospheric moisture. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.