Description

Methyl 4-Chloro-2-Oxo-2H-Chromene-3-Carboxylate is a synthetically derived coumarin derivative featuring a chloro-substituted lactone core and an ester functional group at the 3-position. This compound serves as a high-value intermediate in the development of anticoagulant agents, kinase inhibitors, and fluorescent probes due to its structural rigidity, photophysical tunability, and reactivity profile. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and agrochemical innovators requiring regioselectively functionalizable heterocyclic scaffolds. Methyl 4-Chloro-2-Oxo-2H-Chromene-3-Carboxylate CAS NO 213181-25-0 is supplied under stringent quality controls to ensure batch-to-batch reproducibility and synthetic reliability.

Application

• Key synthetic intermediate for novel vitamin K antagonist anticoagulants (e.g., next-generation warfarin analogs)
• Building block in medicinal chemistry for serine/threonine kinase inhibitor programs targeting oncology indications
• Core scaffold in the design of environment-sensitive fluorescent dyes for cellular imaging and biosensor development
• Reagent in heterocyclic cross-coupling reactions (e.g., Suzuki, Heck) to access polyfunctionalized chromene libraries
• Starting material for the preparation of 3-substituted 4-chlorocoumarins with enhanced metabolic stability
• Substrate in asymmetric catalysis studies exploring enantioselective lactone ring-opening or C–H functionalization
• Component in photoactive polymer additives for UV-curable coatings and optical materials
• Reference standard and calibration material for HPLC-UV and LC-MS/MS method validation in regulatory testing labs

Basic Information

Product Name	Methyl 4-Chloro-2-Oxo-2H-Chromene-3-Carboxylate
CAS No.	213181-25-0
Molecular Formula	C11H7ClO4
Molecular Weight	238.63 g/mol
Synonyms	4-Chloro-3-(methoxycarbonyl)-2H-chromen-2-one; Methyl 4-chloro-2-oxo-2H-1-benzopyran-3-carboxylate; Methyl 4-chloro-2-oxocoumarin-3-carboxylate; 4-Chloro-3-carbomethoxycoumarin; MCOC; 4-Chloro-3-methoxycarbonylcoumarin; NSC 162794; 2H-1-Benzopyran-3-carboxylic acid, 4-chloro-2-oxo-, methyl ester
EINECS	Not listed

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches are verified for identity (IR, HPLC retention time), purity (≥98.5% by HPLC), residual solvents (ICH Q3C compliant), heavy metals (≤10 ppm), and water content (Karl Fischer titration). Testing adheres to ISO/IEC 17025-accredited protocols where applicable, and manufacturing follows cGMP-aligned practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C in a dry, well-ventilated area. Due to its hygroscopic nature, minimize exposure to ambient humidity; use desiccant storage when opened. Avoid prolonged contact with stainless steel or aluminum surfaces under humid conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Single impurity ≤0.3%; Total impurities ≤0.5%
Residue on Ignition	≤0.1%
Water (KF)	≤0.5%
Heavy Metals	≤10 ppm
Solubility	Soluble in DCM, DMF, acetone; slightly soluble in methanol; insoluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.