Description

3,6,9,12-Tetraoxatetradecane-1,14-Diyl-Bis-Methanethiosulfonate is a specialized bifunctional thiosulfonate compound, also known as a bis-methanethiosulfonate (bis-MTS) crosslinker. Its primary value lies in its ability to act as a highly specific, reversible crosslinking agent for introducing disulfide bonds or for site-directed spin labeling in protein engineering and structural biology. This product is essential for researchers and manufacturers in the fields of bioconjugation, protein chemistry, and advanced material science, where precise molecular modification and stabilization are required.

Application

• Protein Crosslinking and Stabilization: Used to introduce specific, reversible disulfide bridges into proteins to study folding, stability, and dynamics.
• Site-Directed Spin Labeling (SDSL): A key reagent for attaching spin labels to cysteine residues in proteins for Electron Paramagnetic Resonance (EPR) spectroscopy studies.
• Bioconjugation and Protein Modification: Enables the controlled attachment of peptides, proteins, or other molecules via disulfide bond formation.
• Structural Biology Research: Facilitates the analysis of protein structure, conformational changes, and intermolecular interactions.
• Development of Diagnostic Reagents: Used in the synthesis of labeled antibodies and other protein-based detection tools.
• Polymer and Material Functionalization: Serves as a linker for modifying surfaces or polymers with thiol-reactive groups.

Basic Information

Product Name	3,6,9,12-Tetraoxatetradecane-1,14-Diyl-Bis-Methanethiosulfonate
CAS No.	212262-08-3
Molecular Formula	C12H24O10S4
Molecular Weight	456.57 g/mol
Synonyms	Bis-MTS-PEG4; 1,11-Bis(methanethiosulfonate)-3,6,9-trioxaundecane; PEG4 bis-methanethiosulfonate; MTSL-PEG4-MTSL; DTSSP-PEG4; Polyethylene glycol bis(methanethiosulfonate) (n=4); Bis(methanethiosulfonylethoxy)ethoxyethyl ether; 1,14-Bis(methanethiosulfonyl)-3,6,9,12-tetraoxatetradecane
EINECS	Contact for details

Quality Control

Our 3,6,9,12-Tetraoxatetetradecane-1,14-Diyl-Bis-Methanethiosulfonate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and structural confirmation by NMR and MS, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.