Description

3,6,9-Trioxaundecane-1,11-Diyl-Bismethanethiosulfonate is a specialized organic sulfur compound featuring a polyethylene glycol-like spacer linked to two methanethiosulfonate groups. This unique bifunctional structure makes it a valuable intermediate for bioconjugation and cross-linking applications, particularly in the development of advanced materials and biochemical probes. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and specialty polymer sectors who require precise and controllable chemical modification of proteins, peptides, and other macromolecules.

Application

• Bioconjugation Reagent: Used for site-specific modification of cysteine residues in proteins and peptides to attach fluorophores, drugs, or other functional molecules.
• Cross-linking Agent: Serves as a homobifunctional linker for creating protein-protein conjugates or for immobilizing biomolecules onto solid supports.
• Polymer Functionalization: Acts as a key intermediate for introducing thiol-reactive groups into polyethylene glycol (PEG) derivatives and other polymer backbones.
• Surface Modification: Employed to create reactive self-assembled monolayers (SAMs) on gold or other surfaces for biosensor development.
• Antibody-Drug Conjugate (ADC) Research: A potential building block in the synthesis of novel linkers for ADC payload attachment.
• Material Science: Used in the synthesis of functional hydrogels and smart materials with responsive properties.

Basic Information

Product Name	3,6,9-Trioxaundecane-1,11-Diyl-Bismethanethiosulfonate
CAS No.	212262-02-7
Molecular Formula	C11H22O8S4
Molecular Weight	410.54 g/mol
Synonyms	BisMTS-PEG3; 1,11-Bis(methanethiosulfonyl)-3,6,9-trioxaundecane; PEG3 BisMTS; 3,6,9-Trioxaundecane-1,11-diyl bis(methanesulfonothioate); DTME-PEG3; Homobifunctional PEG3 Thiol-Reactive Crosslinker; 1,11-Bis(methanesulfonothioyl)-3,6,9-trioxaundecane; PEG-based Homobifunctional Methanethiosulfonate
EINECS	Contact for details

Quality Control

Our 3,6,9-Trioxaundecane-1,11-Diyl-Bismethanethiosulfonate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at temperatures between 2°C and 8°C (refrigerated) for long-term stability. For short-term use, the product may be kept at controlled room temperature (15-25°C). Allow the container to reach room temperature before opening to minimize moisture condensation. Keep under an inert atmosphere if specified for the specific grade.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.