Description

6-Hydroxyhexyl Methanethiosulfonate is a specialized organosulfur compound featuring a reactive methanethiosulfonate group linked to a hydroxy-terminated hexyl chain. This bifunctional structure makes it a valuable chemical intermediate and a versatile bioconjugation reagent, particularly for site-specific protein and peptide modification. It is primarily utilized by pharmaceutical researchers, biotech companies, and advanced material scientists for developing targeted therapeutics, diagnostic probes, and functionalized polymers.

Application

• Bioconjugation and Protein Labeling: Used for introducing thiol-reactive sites or cross-linking biomolecules via its methanethiosulfonate group.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of drug candidates, especially those requiring thioether linkages or controlled-release mechanisms.
• Polymer Functionalization: Enables the modification of polymer backbones to introduce hydroxyl or thiol-reactive functionalities for advanced material applications.
• Surface Modification Agent: Applied to functionalize gold nanoparticles, biosensor surfaces, and other substrates to create specific binding interfaces.
• Proteomics Research: Acts as a tool compound for studying protein structure, function, and interactions through selective cysteine modification.
• Linker Chemistry: Employed in the design of cleavable linkers for antibody-drug conjugates (ADCs) and other targeted delivery systems.

Basic Information

Product Name	6-Hydroxyhexyl Methanethiosulfonate
CAS No.	212261-98-8
Molecular Formula	C7H16O3S2
Molecular Weight	212.33 g/mol
Synonyms	6-(Methanethiosulfonyloxy)hexan-1-ol; Hexane-1,6-diol monomethanethiosulfonate; 1-Hydroxy-6-(methylsulfonylthio)hexane; MTS-hexanol; 6-Hydroxyhexyl MTS; (6-Hydroxyhexyl) methanesulfonothioate; 6-Hexanol methanethiosulfonate; SS-HEX-OH
EINECS	Contact for details

Quality Control

Our 6-Hydroxyhexyl Methanethiosulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your research and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. The product is light-sensitive and should be handled under inert atmosphere when appropriate to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.