Description

2-Ethynylbenzyl Bromide is a versatile and highly reactive organic bromide building block, characterized by the presence of both an ethynyl and a benzyl bromide functional group. This compound is of significant value in advanced organic synthesis, particularly for constructing complex molecular architectures through cross-coupling and cycloaddition reactions. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for the development of new active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially in constructing fused ring systems and alkyne-linked bioactive molecules.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators that require alkyne or aryl bromide functionalities.
• Material Science & Polymer Chemistry: Serves as a monomer or cross-linking agent for creating specialty polymers with unique optical or electronic properties.
• Organic Synthesis Building Block: Employed in Sonogashira, Suzuki, and other palladium-catalyzed cross-coupling reactions to introduce the 2-ethynylbenzyl moiety.
• Ligand & Catalyst Development: Useful for preparing novel phosphine or N-heterocyclic carbene ligands with tailored steric and electronic properties.
• Chemical Biology Probes: Acts as a labeling reagent or a handle for bio-conjugation via click chemistry (azide-alkyne cycloaddition) strategies.

Basic Information

Product Name	2-Ethynylbenzyl Bromide
CAS No.	211508-95-1
Molecular Formula	C9H7Br
Molecular Weight	195.06 g/mol
Synonyms	1-(Bromomethyl)-2-ethynylbenzene; (2-Ethynylphenyl)methyl Bromide; α-Bromo-2-ethylnyltoluene; o-Ethynylbenzyl Bromide; 2-Ethynyl-α-bromotoluene; Bromo(2-ethynylphenyl)methane
EINECS	Contact for details

Quality Control

Our 2-Ethynylbenzyl Bromide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.