Description

(S)-3-Aminochroman Hydrochloride is a high-purity chiral building block and intermediate of significant importance in modern pharmaceutical synthesis. Its value lies in its enantiomeric purity, which is critical for developing active pharmaceutical ingredients (APIs) with specific and potent biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly within central nervous system (CNS) and cardiovascular drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly for serotonin and norepinephrine reuptake inhibitors.
• Asymmetric Synthesis: Used as a starting material or intermediate in catalytic asymmetric reactions to construct complex molecular architectures.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Chemical Biology Probes: Utilized in the development of molecular probes to study biological pathways and enzyme functions.
• Process Chemistry Development: Integral to scaling up synthetic routes from laboratory to pilot and commercial production scales.

Basic Information

Product Name	(S)-3-Aminochroman Hydrochloride
CAS No.	211506-60-4
Molecular Formula	C10H14ClNO
Molecular Weight	199.68 g/mol
Synonyms	(3S)-3-Amino-3,4-dihydro-2H-1-benzopyran Hydrochloride; (S)-3-Amino-3,4-dihydro-2H-chromene Hydrochloride; (S)-3-Aminochroman HCl; (S)-3-Amino-3,4-dihydro-2H-1-benzopyran Hydrochloride; (S)-3-Amino-3,4-dihydro-2H-chromane Hydrochloride; (S)-3-Amino-3,4-dihydro-2H-benzopyran Hydrochloride; 3-Aminochroman Hydrochloride, (S)-; 211506-60-4
EINECS	Contact for details

Quality Control

Our (S)-3-Aminochroman Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, NMR, and mass spectrometry for structural confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.