Description

Fmoc-Phe(3-I)-Oh CAS NO 210282-31-8 is a protected amino acid derivative, specifically an Fmoc-protected 3-iodo-L-phenylalanine building block. This compound is critical for the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics, where it introduces a halogenated aromatic side chain for further functionalization via cross-coupling reactions. It is an essential raw material for researchers and manufacturers in pharmaceutical R&D, particularly in the development of targeted therapeutics, diagnostic agents, and novel bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the automated synthesis of peptides containing iodinated phenylalanine residues.
• Pharmaceutical Intermediate: Used in the research and development of novel drug candidates, especially those requiring site-specific modification for activity or conjugation.
• Peptidomimetic Design: Enables the creation of modified peptide structures with enhanced stability, bioavailability, or receptor binding affinity.
• Chemical Biology Probes: Serves as a precursor for synthesizing labeled peptides used in imaging, target identification, and mechanism-of-action studies.
• Cross-Coupling Reactions: The iodine atom on the aromatic ring allows for further derivatization via palladium-catalyzed reactions (e.g., Suzuki, Sonogashira) to introduce diverse functional groups.
• Combinatorial Chemistry Libraries: A valuable component for generating libraries of compounds for high-throughput screening in drug discovery.

Basic Information

Product Name	Fmoc-Phe(3-I)-Oh
CAS No.	210282-31-8
Molecular Formula	C24H20INO4
Molecular Weight	513.32 g/mol
Synonyms	Fmoc-3-iodo-L-phenylalanine; N-(9-Fluorenylmethoxycarbonyl)-3-iodo-L-phenylalanine; Fmoc-L-Phe(3-I)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-(3-iodophenyl)propanoic acid; Fmoc-3-I-Phe-OH; N-α-Fmoc-3-iodo-L-phenylalanine; Fmoc-Phe(3-I)-OH; Fmoc-3-Iodo-Phe-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Phe(3-I)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring traceability and consistency for your critical research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.