Description

Boc-1,2-trans-Achc-Oh is a protected amino acid derivative, specifically a trans-2-aminocyclohexanecarboxylic acid with a tert-butoxycarbonyl (Boc) protecting group on the amine. This compound is a crucial chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery and development, particularly for creating constrained peptide structures with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediates: A key chiral synthon for the synthesis of novel therapeutic peptides and protease inhibitors.
• Peptidomimetic Research: Used to incorporate constrained, non-natural amino acids into peptide backbones to improve drug-like properties.
• Solid-Phase Peptide Synthesis (SPPS): Serves as a protected amino acid building block for automated peptide assembly.
• Chemical Biology Probes: Employed in the development of labeled or modified peptides for studying biological pathways and protein interactions.
• Agrochemical Research: Potential intermediate in the development of bioactive compounds with peptide-like structures.
• Academic & Contract Research: Essential for synthetic chemistry research focused on new methodologies for peptide and heterocycle formation.

Basic Information

Product Name	Boc-1,2-trans-Achc-Oh
CAS No.	209128-50-7
Molecular Formula	C₁₂H₂₁NO₄
Molecular Weight	243.30 g/mol
Synonyms	(1R,2S)-2-[(tert-Butoxycarbonyl)amino]cyclohexane-1-carboxylic acid; (1R,2S)-2-[(tert-Butoxycarbonyl)amino]cyclohexanecarboxylic acid; Boc-trans-1,2-ACHC-OH; Boc-(1R,2S)-2-aminocyclohexanecarboxylic acid; tert-Butyl (1R,2S)-2-carboxycyclohexylcarbamate; trans-2-(Boc-amino)cyclohexanecarboxylic acid
EINECS	Contact for details

Quality Control

Our Boc-1,2-trans-Achc-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.