Description

Chloro-N,N,N′,N′-Tetramethylformamidinium Hexafluorophosphate is a high-purity, specialized reagent salt widely used in organic synthesis and peptide chemistry. Its primary value lies in its role as a highly effective coupling agent and activator for the formation of amide bonds and other condensation reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require reliable and efficient reagents for complex molecular assembly.

Application

• Peptide Synthesis: Acts as a potent coupling reagent (e.g., a variant of HATU-type activators) for solid-phase and solution-phase peptide synthesis, facilitating high-yield amide bond formation with minimal racemization.
• Organic Synthesis: Employed as a versatile reagent for activating carboxylic acids in the synthesis of esters, amides, and other derivatives under mild conditions.
• Pharmaceutical Intermediates: Used in the production of active pharmaceutical ingredients (APIs) and complex drug candidates that require precise and efficient coupling steps.
• Bioconjugation: Facilitates the labeling and conjugation of biomolecules, such as proteins and peptides, with various probes or other functional molecules.
• Materials Science: Applied in the synthesis of specialized polymers and dendrimers where controlled condensation reactions are critical.
• Chemical Research: Serves as a key tool in academic and industrial R&D laboratories for developing new synthetic methodologies and constructing complex molecular architectures.

Basic Information

Product Name	Chloro-N,N,N′,N′-Tetramethylformamidinium Hexafluorophosphate
CAS No.	207915-99-9
Molecular Formula	C5H12ClN2•PF6
Molecular Weight	296.58 g/mol
Synonyms	Chloro-Tris(dimethylamino)phosphonium Hexafluorophosphate; (Chloroimino)dimethylammonium Hexafluorophosphate; TCFH; Chloro-N,N,N',N'-Tetramethylformamidinium PF6; CTFH; Tetramethylchloroformamidinium Hexafluorophosphate; 2-Chloro-1,3-dimethyl-4,5-dihydro-1H-imidazol-3-ium Hexafluorophosphate
EINECS	Contact for details

Quality Control

Our Chloro-N,N,N′,N′-Tetramethylformamidinium Hexafluorophosphate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and ion chromatography, to ensure high chemical purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry atmosphere or under inert gas to maintain stability and prevent decomposition. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.