Description

o-(2-Nitrobenzyl)-L-Tyrosine Hydrochloride is a protected amino acid derivative, specifically a caged or photolabile compound, where the tyrosine phenol group is masked by a 2-nitrobenzyl moiety. This molecular design is critical for applications requiring precise, light-triggered release of the active phenolic group, enabling spatiotemporal control in biological and chemical systems. It is primarily utilized by researchers and manufacturers in advanced pharmaceutical development, proteomics, and the synthesis of photoresponsive biomaterials and probes.

Application

• Photocaging Agent in Biochemistry: Used to create "caged" peptides and proteins, where biological activity is controlled by UV light irradiation to cleave the protecting group.
• Precursor for Photolabile Linkers: Serves as a key building block in solid-phase peptide synthesis (SPPS) for constructing photolabile resins and cleavable linkers.
• Proteomics Research: Employed in activity-based protein profiling (ABPP) and other chemical proteomics strategies to study enzyme function and dynamics.
• Development of Smart Materials: Incorporated into hydrogels and polymer matrices to create light-responsive drug delivery systems and biomimetic scaffolds.
• Synthesis of Molecular Probes: Used to fabricate fluorescent or affinity-based probes for studying intracellular signaling pathways.
• Pharmaceutical Intermediate: Acts as a specialized intermediate in the research and development of novel therapeutic agents.

Basic Information

Product Name	o-(2-Nitrobenzyl)-L-Tyrosine Hydrochloride
CAS No.	207727-86-4
Molecular Formula	C₁₆H₁₇N₂O₅•HCl
Molecular Weight	368.78 g/mol
Synonyms	L-Tyrosine, O-[2-nitrobenzyl]-, hydrochloride; (2S)-2-Amino-3-[4-[(2-nitrobenzyl)oxy]phenyl]propanoic acid hydrochloride; o-Nitrobenzyl-L-tyrosine HCl; 2-Nitrobenzyl-L-tyrosine hydrochloride; Photolabile tyrosine derivative hydrochloride; Caged tyrosine hydrochloride; NBB-L-Tyr-OH•HCl
EINECS	Contact for details

Quality Control

Our o-(2-Nitrobenzyl)-L-Tyrosine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D: Specific range available on COA
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.