Description

Pentafluorophenol-Tetramethyluronium Hexafluorophosphate is a highly reactive peptide coupling reagent, specifically an uronium salt activator. This compound is critical for facilitating efficient amide bond formation in solid-phase peptide synthesis (SPPS) and solution-phase chemistry, offering advantages in coupling speed and reduced racemization. It is an essential tool for researchers and manufacturers in pharmaceutical development, biotechnology, and advanced organic synthesis who require high-purity, reliable reagents for constructing complex peptides and other sensitive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key activator for coupling amino acids, especially for sterically hindered or non-standard residues.
• Solution-Phase Peptide Coupling: Used in the synthesis of peptide fragments and small peptides in organic solvents.
• Pharmaceutical Intermediate Manufacturing: Employed in the production of active pharmaceutical ingredients (APIs) and peptide-based drugs.
• Bioconjugation: Facilitates the coupling of peptides to proteins, polymers, or other biomolecules for drug delivery systems and diagnostics.
• Organic Synthesis: Acts as a condensing agent for the formation of esters, amides, and other carboxylic acid derivatives beyond peptide chemistry.
• Research & Development: A staple reagent in R&D laboratories for exploring new synthetic methodologies and compound libraries.

Basic Information

Product Name	Pentafluorophenol-Tetramethyluronium Hexafluorophosphate
CAS No.	206190-14-9
Molecular Formula	C11H12F11N2OP
Molecular Weight	440.19 g/mol
Synonyms	PFP-TMU-HFP; Pentafluorophenyl Tetramethyluronium Hexafluorophosphate; 2-(2,3,4,5,6-Pentafluorophenoxy)-1,1,3,3-tetramethyluronium Hexafluorophosphate; HATU Analogue (Pfp-based); Pentafluorophenol O-(Tetramethyluronium) Hexafluorophosphate; Coupling Reagent 206190-14-9; Tetramethyl-O-(pentafluorophenyl)uronium Hexafluorophosphate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized to confirm identity, purity, and performance suitability for sensitive synthetic applications. Certificates of Analysis (COA) with detailed HPLC assay, NMR, and other relevant analytical data are available upon request. We adhere to strict in-house quality protocols to ensure batch-to-batch consistency and reliability for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry, inert atmosphere (e.g., nitrogen or argon) when possible to maintain optimal reactivity and shelf life. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Performance Test	Passes standard peptide coupling test

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.