Description

2-(2-Chlorophenyl)-8-((3S,4R)-3-Hydroxy-1-Methylpiperidin-4-Yl)-5,7-Dimethoxy-4H-Chromen-4-One is a high-purity, structurally complex chromen-4-one derivative that serves as a critical advanced intermediate in pharmaceutical research and development. Its precise stereochemistry and functional groups make it a valuable building block for synthesizing novel therapeutic agents targeting specific biological pathways. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) or metabolic disorder targets.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Process Chemistry & Scale-Up: Serves as a defined intermediate for optimizing synthetic routes and scaling up production from laboratory to pilot plant scale.
• Reference Standard: Employed as an analytical standard for quality control, method development, and regulatory submissions in pharmaceutical manufacturing.
• Biochemical Probe Development: Utilized in academic and industrial research to create tool compounds for investigating enzyme mechanisms or receptor interactions.
• Fine Chemical Synthesis: Building block for the synthesis of other specialized, high-value chromenone and flavone derivatives.

Basic Information

Product Name	2-(2-Chlorophenyl)-8-((3S,4R)-3-Hydroxy-1-Methylpiperidin-4-Yl)-5,7-Dimethoxy-4H-Chromen-4-One
CAS No.	205506-16-7
Molecular Formula	C23H24ClNO5
Molecular Weight	429.90 g/mol
Synonyms	8-[(3S,4R)-3-Hydroxy-1-methyl-4-piperidinyl]-2-(2-chlorophenyl)-5,7-dimethoxy-4H-1-benzopyran-4-one; (3S,4R)-4-[2-(2-Chlorophenyl)-5,7-dimethoxy-4-oxo-4H-chromen-8-yl]-1-methylpiperidin-3-ol; 2-(2-Chlorophenyl)-5,7-dimethoxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-chromen-4-one; Chromen-4-one derivative CAS 205506-16-7; 8-(3-Hydroxy-1-methylpiperidin-4-yl)-2-(2-chlorophenyl)-5,7-dimethoxychromen-4-one (stereospecific)
EINECS	Contact for details

Quality Control

Our 2-(2-Chlorophenyl)-8-((3S,4R)-3-Hydroxy-1-Methylpiperidin-4-Yl)-5,7-Dimethoxy-4H-Chromen-4-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for stereochemical purity, to ensure compliance with research-grade and cGMP standards for advanced intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain stability. Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.