Description

Epimedin I is a bioactive flavonoid glycoside, a key marker compound for the standardization of extracts derived from *Epimedium* species. Its precise quantification is critical for ensuring the potency, efficacy, and batch-to-batch consistency of herbal formulations and nutraceutical products. This high-purity reference standard is essential for research institutions, analytical laboratories, and manufacturers in the pharmaceutical, dietary supplement, and botanical extract industries who require reliable materials for quality control, method development, and biological activity studies.

Application

• Pharmaceutical Reference Standard: Used as a primary chemical reference material (CRM) for the identification and assay of Epimedium-based drugs and preparations in pharmacopoeial testing (e.g., Chinese Pharmacopoeia).
• Dietary Supplement QC/QA: Serves as a critical marker for the standardization and quality assurance of commercial herbal supplements containing Horny Goat Weed (*Epimedium*) extracts to guarantee labeled potency.
• Biomedical Research: Employed in *in vitro* and *in vivo* studies to investigate its pharmacological properties, including potential effects on bone metabolism, cardiovascular health, and neuroprotection.
• Analytical Method Development: Essential for developing and validating precise analytical methods such as HPLC, LC-MS, and TLC for the quantification of flavonoid components in complex botanical matrices.
• Botanical Extract Manufacturing: Used to calibrate equipment and verify the concentration of active constituents during the extraction, purification, and finishing processes of Epimedium raw materials.
• Regulatory Compliance & Documentation: Provides the certified material necessary for generating regulatory submissions, stability studies, and Certificates of Analysis (CoA) for GMP-compliant production.

Basic Information

Product Name	Epimedin I
CAS No.	205445-00-7
Molecular Formula	C₃₉H₅₀O₁₉
Molecular Weight	838.81 g/mol
Synonyms	Epimedin A; Epimedoside A; Icariside B; 3-[[6-Deoxy-2-O-(6-deoxy-α-L-mannopyranosyl)-α-L-mannopyranosyl]oxy]-5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one; Epimedium Flavonoid Glycoside; Epimedin C1 (related compound)
EINECS	Contact for details

Quality Control

Our Epimedin I is produced under strict quality management protocols. Each batch undergoes comprehensive identity confirmation and purity analysis using advanced chromatographic (HPLC, TLC) and spectroscopic (MS, NMR) techniques. We provide full traceability and a detailed Certificate of Analysis (CoA) specifying purity, related substances, and residual solvents, ensuring compliance with research and quality control standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.