Description

4-Chloro-3-Fluorocinnamic Acid is a halogenated cinnamic acid derivative serving as a versatile and high-value synthetic building block. Its molecular structure, featuring both chloro and fluoro substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, where it is used to develop new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting inflammation, oncology, and central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and plant growth regulators, leveraging its halogenated aromatic core.
• Liquid Crystal & OLED Materials: Serves as a precursor for synthesizing fluorinated organic semiconductors and liquid crystal compounds for display technologies.
• Chemical Research & Development: A valuable reagent in organic synthesis for Suzuki-Miyaura and other cross-coupling reactions to create complex biaryl structures.
• Peptide Mimetics & Bio-conjugates: The carboxylic acid group allows for conjugation, making it useful in creating peptide analogs and probe molecules for biochemical studies.

Basic Information

Product Name	4-Chloro-3-Fluorocinnamic Acid
CAS No.	202982-66-9
Molecular Formula	C9H6ClFO2
Molecular Weight	200.59 g/mol
Synonyms	(E)-3-(4-Chloro-3-fluorophenyl)acrylic acid; 3-(4-Chloro-3-fluorophenyl)-2-propenoic acid; 4-Chloro-3-fluorocinnamic acid; trans-4-Chloro-3-fluorocinnamic acid; (2E)-3-(4-Chloro-3-fluorophenyl)prop-2-enoic acid; 4-Chloro-3-fluoro-trans-cinnamic acid; 202982-66-9; 4-Cl-3-F-CA
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-Fluorocinnamic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) with lot-specific data are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and heat sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.