Description

Methyl 2-Trifluoromethanesulfonyloxy-1-Naphthoate is a high-purity, specialized chemical intermediate featuring a reactive trifluoromethanesulfonate (triflate) ester group. This compound is valued for its role as a versatile building block in advanced organic synthesis, enabling critical carbon-carbon and carbon-heteroatom bond-forming reactions. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs), particularly those requiring naphthalene-based scaffolds.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides, leveraging its reactivity to introduce functional groups.
• Cross-Coupling Reactions: Serves as an excellent electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) for constructing biaryl systems.
• Material Science Research: Employed in the development of organic electronic materials, such as semiconductors and light-emitting diodes (OLEDs), where its structure can be incorporated into conjugated systems.
• Nucleophilic Substitution: The triflate group is an excellent leaving group, facilitating nucleophilic substitution reactions with a wide range of nucleophiles.
• Laboratory Scale Organic Synthesis: A valuable reagent for medicinal and process chemists in exploratory synthesis and route scouting for new chemical entities.

Basic Information

Product Name	Methyl 2-Trifluoromethanesulfonyloxy-1-Naphthoate
CAS No.	200573-11-1
Molecular Formula	C₁₃H₉F₃O₅S
Molecular Weight	334.27 g/mol
Synonyms	Methyl 2-((trifluoromethyl)sulfonyloxy)-1-naphthoate; 1-Naphthalenecarboxylic acid, 2-[(trifluoromethyl)sulfonyl]oxy-, methyl ester; Methyl 2-triflyloxy-1-naphthoate; 2-Trifluoromethanesulfonyloxy-1-naphthoic acid methyl ester; Methyl 2-(trifluoromethanesulfonyloxy)naphthalene-1-carboxylate; Methyl 2-OTf-1-naphthoate; 1-Naphthoic acid, 2-(trifluoromethanesulfonyloxy)-, methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 2-Trifluoromethanesulfonyloxy-1-Naphthoate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.