Description

Mbs-D-Arg-Oh CAS NO 200188-25-6 is a protected derivative of the amino acid D-Arginine, featuring a 4-methoxybenzenesulfonyl (Mbs) protecting group on the guanidino side chain. This compound is critical for enabling selective peptide synthesis and modification, particularly in the creation of complex, biologically active molecules where the unique properties of the D-arginine enantiomer are required. It serves as a key chiral building block for researchers and manufacturers in pharmaceutical development, proteomics, and advanced biochemical research, ensuring high-purity, stereochemically defined intermediates.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon in the research and development of novel peptide-based therapeutics and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate D-arginine residues while protecting the reactive guanidino group from side reactions.
• Bioconjugation & Probe Development: Serves as a modified amino acid for creating labeled peptides, affinity probes, and diagnostic tools in biochemical research.
• Enzyme Substrate & Inhibitor Studies: Employed in the study of enzyme specificity, particularly for proteases and kinases, due to its non-natural D-configuration.
• Glycopeptide & Lipopeptide Synthesis: Facilitates the synthesis of complex modified peptides where the arginine side chain must be selectively unmasked in later synthesis steps.
• Academic & Industrial R&D: A fundamental reagent for chemical biology and medicinal chemistry research in academic institutions and biotechnology companies.

Basic Information

Product Name	Mbs-D-Arg-Oh
CAS No.	200188-25-6
Molecular Formula	C14H22N4O5S
Molecular Weight	358.41 g/mol
Synonyms	D-Arginine, N2-[(4-methoxyphenyl)sulfonyl]-; (R)-2-Amino-5-[(4-methoxybenzenesulfonyl)amino]pentanoic acid; N(omega)-Mbs-D-arginine; N(omega)-(4-Methoxybenzenesulfonyl)-D-arginine; H-D-Arg(Mbs)-OH; D-Arg(Mbs)-OH; Mbs-D-Arg; Nω-Mbs-D-arginine
EINECS	Contact for details

Quality Control

Our Mbs-D-Arg-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and NMR and MS for structural confirmation. We provide Certificates of Analysis (COA) with detailed specifications for every shipment, ensuring traceability and compliance with research and cGMP-grade requirements for advanced synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.