Description

Burgess Reagent CAS NO 29684-56-8 is a highly versatile and powerful dehydrating agent, specifically N-(triethylammoniumsulfonyl)carbamate. Its core value lies in its exceptional ability to facilitate the synthesis of nitriles from primary amides and to promote the dehydration of secondary amides to nitriles under mild conditions, offering superior yields and selectivity. This makes it an indispensable tool for synthetic organic chemists and process development scientists. Key industries that rely on this reagent include pharmaceutical intermediates, agrochemicals, and advanced material research, where efficient and clean synthetic transformations are critical.

Application

• Synthesis of Nitriles: Primary application for the efficient, one-step conversion of primary amides to their corresponding nitriles.
• Dehydration of Amides: Effective for converting secondary amides to nitriles, a valuable transformation in complex molecule synthesis.
• Pharmaceutical Intermediate Manufacturing: Used in key steps for building blocks containing cyano groups, which are prevalent in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Employed in the production of herbicides, fungicides, and insecticides that utilize nitrile functionalities.
• Material Science Research: Facilitates the creation of novel polymers and liquid crystals where nitrile groups modify physical properties.
• Peptide Chemistry: Can be used in specific deprotection or modification steps under controlled conditions.
• Academic & Process R&D: A reagent of choice in research laboratories for developing new synthetic methodologies.

Basic Information

Product Name	Burgess Reagent
CAS No.	29684-56-8
Molecular Formula	C8H20N2O3S
Molecular Weight	224.32 g/mol
Synonyms	Burgess Reagent; (Methoxycarbonylsulfamoyl)triethylammonium Hydroxide Inner Salt; Ethyl (Triethylammoniosulfonyl)carbamate; Triethylammonium N-(Methoxycarbonylsulfamoyl)carbamate; N-(Triethylammoniumsulfonyl)carbamic Acid Methyl Ester; Methyl N-(Triethylammoniosulfonyl)carbamate; Burgess Dehydrating Reagent
EINECS	Contact for details

Quality Control

Our Burgess Reagent is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high reactivity. We provide material that meets the exacting standards required for research and industrial-scale synthesis. A comprehensive Certificate of Analysis (COA) is supplied with each batch, detailing key parameters such as purity, identity, and moisture content. Our quality system is designed to support applications in cGMP environments where documentation and traceability are paramount.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a cool, dry place. For long-term stability, store at 2-8°C under an inert atmosphere such as argon or nitrogen. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in common organic solvents (DCM, THF, DMF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.