Description

trans-4-Cbz-Aminocyclohexyl p-Toluenesulphonate is a high-purity, protected amino acid derivative and versatile synthetic building block. This compound is critical for the controlled introduction of a trans-4-aminocyclohexyl moiety in complex organic syntheses, particularly in pharmaceutical research. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing novel drug candidates and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of small molecule drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Peptidomimetic Chemistry: Used to incorporate constrained, cyclohexyl-based amino acid analogs into peptide chains to enhance metabolic stability and bioavailability.
• Protease Inhibitor Development: Serves as a precursor for inhibitors where the aminocyclohexyl group is a key pharmacophore.
• Chemical Biology & Proteomics: Employed in the synthesis of activity-based probes and affinity tags for studying enzyme function.
• Library Synthesis: A valuable reagent for generating diverse compound libraries in high-throughput screening and drug discovery campaigns.
• Custom Synthesis & Contract Manufacturing: Used by CDMOs for the cGMP and non-GMP production of complex Active Pharmaceutical Ingredients (APIs) and advanced intermediates.

Basic Information

Product Name	trans-4-Cbz-Aminocyclohexyl p-Toluenesulphonate
CAS No.	29493-38-7
Molecular Formula	C21H25NO5S
Molecular Weight	403.49 g/mol
Synonyms	trans-4-[(Benzyloxy)carbonylamino]cyclohexyl 4-methylbenzenesulfonate; (1r,4r)-4-[(Benzyloxycarbonyl)amino]cyclohexyl Tosylate; trans-4-(N-Cbz-Amino)cyclohexyl Tosylate; 4-[[(Benzyloxy)carbonyl]amino]cyclohexyl 4-methylbenzenesulfonate (trans); trans-N-Cbz-4-Aminocyclohexanol Tosylate; p-Toluenesulfonic Acid trans-4-(Cbz-amino)cyclohexyl Ester; trans-4-(Cbz-Amino)cyclohexyl p-Toluenesulfonate
EINECS	Contact for details

Quality Control

Our trans-4-Cbz-Aminocyclohexyl p-Toluenesulphonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production standards. Custom purity grades and analytical packages are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.