Description

2-Isopropyl-1,1,3,3-Tetramethylguanidine is a sterically hindered, strong organic base widely used as a non-nucleophilic catalyst and reagent in organic synthesis. Its high basicity and low nucleophilicity make it exceptionally valuable for promoting reactions where traditional bases may cause unwanted side reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for applications like deprotonation, condensation, and polymerization.

Application

• Pharmaceutical Synthesis: As a catalyst in the production of active pharmaceutical ingredients (APIs), particularly for base-catalyzed reactions like Knoevenagel condensations and Michael additions.
• Polymer Chemistry: A key catalyst for the production of polyurethanes, polycarbonates, and epoxy resins, where it controls reaction rates and polymer properties.
• Agrochemical Manufacturing: Used in the synthesis of pesticides and herbicides, facilitating reactions to build complex molecular structures.
• Fine Chemical Production: Employed as a strong, non-nucleophilic base in the synthesis of dyes, flavors, and fragrances.
• Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new synthetic methodologies and developing novel compounds.
• Cross-Coupling Reactions: Acts as a base in palladium-catalyzed cross-coupling reactions, such as Suzuki and Heck reactions, to form carbon-carbon bonds.

Basic Information

Product Name	2-Isopropyl-1,1,3,3-Tetramethylguanidine
CAS No.	29166-71-0
Molecular Formula	C9H21N3
Molecular Weight	171.28 g/mol
Synonyms	2-Isopropyl-1,1,3,3-tetramethylguanidine; 1,1,3,3-Tetramethyl-2-isopropylguanidine; TMG-iPr; iPr-TMG; ITMG; Tetramethylisopropylguanidine; N,N,N',N'-Tetramethyl-N''-(propan-2-yl)guanidine; Strong Base 1,1,3,3-Tetramethyl-2-isopropylguanidine
EINECS	249-474-5

Quality Control

Our 2-Isopropyl-1,1,3,3-Tetramethylguanidine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of industrial and research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.460 - 1.470
Density (20°C)	0.88 - 0.92 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.