Description

(Z)-2-Methyl-2-Butenoic Acid [(2S)-2α-(1-Acetoxy-1-Methylethyl)-2,3-Dihydro-7-Oxo-7H-Furo[3,2-G][1]Benzopyran-3α-Yl] Ester is a high-purity, complex organic ester with a defined stereochemistry, serving as a critical advanced intermediate in pharmaceutical synthesis. Its precise molecular architecture makes it valuable for constructing specific chiral centers and complex ring systems found in active pharmaceutical ingredients. This compound is primarily required by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the development and production of specialized therapeutics.

Application

This specialized chemical intermediate is designed for high-value synthesis applications where structural precision is paramount.

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules, particularly those containing fused furanobenzopyran structures.
• Chiral Synthesis: Utilized in asymmetric synthesis and resolution processes to introduce specific stereochemical configurations into target compounds.
• Medicinal Chemistry Research: Serves as a precursor or scaffold in drug discovery programs for developing new chemical entities with potential biological activity.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development, validation, and quality control testing.
• Fine Chemical Production: Intermediate in the manufacture of other specialized, high-value fine chemicals and advanced materials.

Basic Information

Product Name	(Z)-2-Methyl-2-Butenoic Acid [(2S)-2α-(1-Acetoxy-1-Methylethyl)-2,3-Dihydro-7-Oxo-7H-Furo[3,2-G][1]Benzopyran-3α-Yl] Ester
CAS No.	28763-06-6
Molecular Formula	C22H26O7
Molecular Weight	402.44 g/mol
Synonyms	(Z)-2-Methylbut-2-enoic acid [(2S,3aR,9bR)-2-(1-acetoxy-1-methylethyl)-2,3,3a,9b-tetrahydro-7-oxofuro[3,2-g]chromen-3a-yl] ester; (Z)-Tiglic Acid [(2S,3aR,9bR)-2-(1-Acetoxy-1-methylethyl)-2,3,3a,9b-tetrahydro-7-oxofuro[3,2-g]chromen-3a-yl] Ester; (2S,3aR,9bR)-3a-[[(2Z)-2-Methyl-2-butenoyl]oxy]-2-(2-hydroxypropan-2-yl)-2,3,3a,9b-tetrahydro-7H-furo[3,2-g]chromen-7-one 2-acetate; Visnagalin; Khellol tiglate ester; Khellol tiglate; A related derivative of Khellin.
EINECS	Contact for details

Quality Control

Our (Z)-2-Methyl-2-Butenoic Acid [(2S)-2α-(1-Acetoxy-1-Methylethyl)-2,3-Dihydro-7-Oxo-7H-Furo[3,2-G][1]Benzopyran-3α-Yl] Ester is produced under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure identity, strength, and purity meet exacting standards. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from direct light sources to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.