Description

(17R)-17-(Trimethylsiloxy)-19-Norpregn-4-En-20-Yn-3-One is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functional groups. This compound is critical for the synthesis of complex steroid-based active pharmaceutical ingredients (APIs) and other fine chemicals, where precise molecular architecture is paramount. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of steroid-derived active pharmaceutical ingredients (APIs).
• Steroid Hormone Research: Used in academic and industrial R&D for studying structure-activity relationships and developing new hormonal therapies.
• Process Chemistry Development: Serves as a critical precursor for optimizing scalable and cost-effective synthetic routes in pilot plants and commercial manufacturing.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Fine Chemical Synthesis: Utilized in the production of other specialized, high-value organic compounds for various research applications.

Basic Information

Product Name	(17R)-17-(Trimethylsiloxy)-19-Norpregn-4-En-20-Yn-3-One
CAS No.	28426-43-9
Molecular Formula	C25H38O2Si
Molecular Weight	398.66 g/mol
Synonyms	17β-(Trimethylsiloxy)-19-norpregn-4-en-20-yn-3-one; (17R)-17-[(Trimethylsilyl)oxy]-19-norpregn-4-en-20-yn-3-one; 19-Norpregn-4-ene-3,20-dione, 17-(trimethylsiloxy)-, (17R)-; 17β-TMS-Ethynyl-19-norandrost-4-en-3-one; 17β-(Trimethylsilyloxy)-19-nor-17α-pregn-4-en-20-yn-3-one; 17-TMS-19-Nor-17α-pregna-4,20-dien-3-one; Ethynylestrenolone TMS ether; Lynestrenol trimethylsilyl ether
EINECS	Contact for details

Quality Control

Our (17R)-17-(Trimethylsiloxy)-19-Norpregn-4-En-20-Yn-3-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.