Description

4-(Trimethylsiloxy)Phenylacetic Acid Methyl Ester is a specialized organosilicon compound featuring a phenylacetic acid methyl ester core protected by a trimethylsilyl (TMS) ether group. This unique structure makes it a valuable protected intermediate and building block in advanced organic synthesis, particularly for pharmaceuticals and fine chemicals. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require high-purity, functionalized intermediates for complex molecule assembly.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring phenolic or carboxylic acid functionality introduced in a controlled manner.
• Peptide Mimetics & Prodrug Synthesis: Used to introduce protected phenylacetic acid derivatives into peptide backbones or as a component in prodrug strategies.
• Agrochemical Synthesis: Intermediate in the production of advanced herbicides, fungicides, and plant growth regulators.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing functionalized aromatic compounds used in electronic displays and organic semiconductors.
• Polymer Modification: Employed to introduce siloxy-protected aromatic groups into polymer chains to modify physical properties.
• Cross-Coupling Reactions: Acts as a substrate in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) due to its reactive ester group.
• Organic Synthesis Reagent: A versatile reagent for introducing the 4-(hydroxyphenyl)acetic acid moiety in a protected form, preventing unwanted side reactions.

Basic Information

Product Name	4-(Trimethylsiloxy)Phenylacetic Acid Methyl Ester
CAS No.	27798-62-5
Molecular Formula	C₁₂H₁₈O₃Si
Molecular Weight	238.35 g/mol
Synonyms	Methyl 2-[4-(trimethylsilyloxy)phenyl]acetate; Methyl (4-trimethylsilyloxyphenyl)acetate; 4-(Trimethylsilyloxy)benzeneacetic acid methyl ester; Methyl 4-(trimethylsiloxy)phenylacetate; p-(Trimethylsiloxy)phenylacetic acid methyl ester; Acetic acid, 2-[4-(trimethylsilyloxy)phenyl]-, methyl ester; Methyl (4-hydroxyphenyl)acetate trimethylsilyl ether
EINECS	Contact for details

Quality Control

Our 4-(Trimethylsiloxy)Phenylacetic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the high standards required for cGMP and R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (by GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.